Proteomic analysis of lysosomes isolated from the brain tissue of VPS35[D620N] mice treated in vivo with MLi-2 (100 mg/kg via oral gavage, 2 h). Tag expression was determined by genotyping PCR and brain lysate immunoblotting. Data acquired on an Orbitrap Exploris 480 and processed using DIA-NN 1.8.1. ASAP Team: Alessi Dataset Name: alessi-mouse-ms-p-brain-vps35-d620n-dmso-mli2, v1.0 Principal Investigator: Dario Alessi Co-Principal Investigator: Suzanne Pfeffer Contributors: Lam, Pui Yiu; Dickie, Emily Sample Summary: Resources and Additional Information Protocols GitHub: NA Protocols: https://doi.org/10.17504/protocols.io.x54v9d61zg3e/v1 10.17504/protocols.io.kxygxzrokv8j/v1 Dataset DOI: https://doi.org/10.5281/zenodo.18476402 Associated Publications: NA CRN Cloud GitHub: https://github.com/ASAP-CRN CRN Cloud Data Dictionary: https://storage.googleapis.com/asap-public-assets/wayfinding/ASAP-CRN-Cloud-Data-Dictionary.pdf CRN Cloud Release Number: v4.1.0 CRN Cloud DOI: https://doi.org/10.5281/zenodo.15831269 CDE Schema Version: v4.3 Verily Workbench is the preferred environment for conducting analysis on all data collections. Please see the reference workspace on Verily...
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Quantitative DIA-based proteomic analysis of lysosomes (Lyso-IP) from VPS35[D620N] Mouse Brain with LRRK2 inhibition is published on ASAP CRN Cloud.